Články

ÚSTAV MOLEKULÁRNÍ GENETIKY AV ČR, v. v. i., Praha

- Králová J, Jurášek M, Krčová L, Dolenský B, Novotný I, Dušek M, Rottnerová Z, Kahle M, Drašar P, Bartůněk P, Král V. Heterocyclic sterol probes for live monitoring of sterol trafficking and lysosomal storage disorders. Sci Rep. 2018 Sep 26;8(1):14428. PubMed, DOI

- Oltova J, Jindrich J, Skuta C, Svoboda O, Machonova O, Bartunek P. Zebrabase: An Intuitive Tracking Solution for Aquatic Model Organisms. Zebrafish. 2018 Sep 20. [Epub ahead of print] PubMED, DOI

- Jurášek M, Černohorská M, Řehulka J, Spiwok V, Sulimenko T, Dráberová E, Darmostuk M, Gurská S, Frydrych I, Buriánová R, Ruml T, Hajdúch M, Bartůněk P, Dráber P, Džubák P, Drašar PB, Sedlák D. Estradiol Dimer Inhibits Tubulin Polymerization and Microtubule Dynamics. J Steroid Biochem Mol Biol. 2018 May 24 [Epub ahead of print] PubMed, DOI

- Brustikova K, Sedlak D, Kubikova J, Skuta C, Solcova K., Malik R, Bartunek P, and Svoboda P. Cell-based reporter system for high-throughput screening of microRNA pathway inhibitors and its limitations. Frontiers in Genetics. 2018 February 27; 9:45. PubMed, DOI

- Rárová L, Sedlák D, Oklestkova J, Steigerová J, Liebl 5, Zahler S, Bartůněk P, Kolář Z, Kohout L, Kvasnica M, Strnad M. The novel brassinosteroid analog BR4848 inhibits angiogenesis in human endothelial cells and induces apoptosis in human cancer cells in vitro. J Steroid Biochem Mol Biol. 2018 Apr; 178:263-271. Epub 2018 Jan 4. PubMed, DOI

- Horký P, Voráčová M, Konečná K, Sedlák D, Bartůněk P, Vacek J, Kuneš J, Pour M. Nontoxic combretafuranone analogues with high in vitro antibacterial activity. Eur J Med Chem. 2018 Jan 1;143:843-853.  PubMed, DOI

2017

- the November 2017 issue of Chemické listy dedicated to computational drug design from CZ-OPENSCREEN authors.

- Grekov I, Pombinho AR, Kobets T, Bartůněk P, Lipoldová M. Calcium Ionophore, Calcimycin, Kills Leishmania Promastigotes by Activating Parasite Nitric Oxide Synthase. Biomed Res Int. 2017; 2017:1309485. doi: 10.1155/2017/1309485. Epub 2017 Oct 18. PubMed, DOI

- Skuta C, Popr M, Muller T, Jindrich J, Kahle M, Sedlak D, Svozil D, Bartunek P. Probes & Drugs Portal: an interactive, open data resource for chemical biology. Nat Methods. 2017 14(8), pp.759-760. PubMed, DOI

- Seydlová G, Pohl R, Zborníková E, Ehn M, Šimák O, Panova N, Kolář M, Bogdanová K, Večeřová R, Fišer R, Šanderová H, Vítovská D, Sudzinová P, Pospíšil J, Benada O, Křížek T, Sedlák D, Bartůněk P, Krásný L, Rejman D. Lipophosphonoxins II: Design, Synthesis, and Properties of Novel Broad Spectrum Antibacterial Agents. J Med Chem. 2017 Jul 27;60(14):6098-6118 PudMed, DOI

- Kralova J, Kolar M, Kahle M, Truksa J, Lettlova S, Balusikova K, Bartunek P. Glycol porphyrin derivatives and temoporfin elicit resistance to photodynamic therapy by different mechanisms. Sci Rep. 2017 Mar 15;7:44497. PudMed, DOI

- Jurášek M, Džubák P, Rimpelová S, Sedlák D, Konečný P, Frydrych I, Gurská S, Hajdúch M, Bogdanová K, Kolář M, Müller T, Kmoníčková E, Ruml T, Harmatha J, Drašar PB. Trilobolide-steroid hybrids: Synthesis, cytotoxic and antimycobacterial activity. Steroids. 2017 Jan; 117:97-104. PubMed, DOI

2016

- Brezániová I, Hrubý M, Králová J, Král V, Černochová Z, Černoch P, Šlouf M, Kredátusová J, Štěpánek P. (2016) Temoporfin-loaded 1-tetradecanol-based thermoresponsive solid lipid nanoparticles for photodynamic therapy. J. Control Release. 2016 241:34-44. PubMed, DOI

- Biedermann D, Buchta M, Holečková V, Sedlák D, Valentová K, Cvačka J, Bednářová L, Křenková A, Kuzma M, Škuta C, Peikerová Ž, Bartůněk P, Křen V. (2016) Silychristin: Skeletal Alterations and Biological Activities. Journal of Natural Products.79:3086-3092.PubMed, DOI

- Felker A, Nieuwenhuize S, Dolbois A, Blazkova K, Hess C, Low LW, Burger S, Samson N, Carney TJ, Bartunek P, Nevado C, Mosimann C. (2016) In vivo performance and properties of tamoxifen metabolites for CreERT2 control. PLoS One. 11:e0152989. PubMed, DOI

- Rárová L, Steigerová J, Kvasnica M, Bartůněk P, Křížová K, Chodounská H, Kolář Z, Sedlák D, Oklestkova J, Strnad M. (2016) Structure activity relationship studies on cytotoxicity and the effects on steroid receptor of AB-functionalized cholestanes. J Steroid Biochem Mol Biol. 159:154-69. PubMed, DOI

2015

- Bříza T, Králová J, Dolenský B, Rimpelová S, Kejík Z, Ruml T, Hajdúch M, Džubák P, Mikula I, Martásek P, Poučková P, Král V. (2015) Striking antitumor activity of a methinium system with incorporated quinoxaline unit obtained by spontaneous cyclization. Chembiochem. 16:555-8. PubMed, DOI

- Kaplánek R, Jakubek M, Rak J, Kejík Z, Havlík M, Dolenský B, Frydrych I, Hajdúch M, Kolář M, Bogdanová K, Králová J, Džubák P, Král V. (2015) Caffeine-hydrazones as anticancer agents with pronounced selectivity toward T-lymphoblastic leukaemia cells. Bioorg Chem. 60:19-29. PubMed, DOI

- Kaplánek R, Havlík M, Dolenský B, Rak J, Džubák P, Konečný P, Hajdúch M, Králová J, Král V. (2015) Synthesis and biological activity evaluation of hydrazone derivatives based on a Tröger's base skeleton. Bioorg Med Chem. 23:1651-9. PubMed, DOI

- Liegertová M, Pergner J, Kozmiková I, Fabian P, Pombinho AR, Strnad H, Pačes J, Vlček Č, Bartůněk P, Kozmik Z. (2015) Cubozoan genome illuminates functional diversification of opsins and photoreceptor evolution. Sci Rep. 5:11885. PubMed, DOI

2014

- Škuta C, Bartůněk P, Svozil D. (2014) InCHlib - interactive cluster heatmap for web applications. J Cheminform. 6:44. PubMed, DOI

- Hoksza D, Skoda P, Voršilák M, Svozil D. (2014) Molpher: a software framework for systematic chemical space exploration. J Cheminform. 6:7. PubMed, DOI

- Tumova L, Pombinho AR, Vojtechova M, Stancikova J, Gradl D, Krausova M, Sloncova E, Horazna M, Kriz V, Machonova O, Jindrich J, Zdrahal Z, Bartunek P, Korinek V. (2014) Monensin inhibits canonical Wnt signaling in human colorectal cancer cells and suppresses tumor growth in multiple intestinal neoplasia mice. Mol Cancer Ther. 13:812-22. PubMed, DOI

- Podolska K, Sedlak D, Bartunek P, Svoboda P. (2014) Fluorescence-based high-throughput screening of dicer cleavage activity. J Biomol Screen. 19:417-26. PubMed, DOI

- Sedlák D, Eignerová B, Dračinský M, Janoušek Z, Bartůněk P, Kotora M. (2014) Synthesis and evaluation of 17 alpha-(carboranylalkyl)estradiols as ligands for estrogen receptors alpha and beta, J Organometal Chem. 747:178-83. DOI

2013

- Beranova L, Pombinho AR, Spegarova J, Koc M, Klanova M, Molinsky J, Klener P, Bartunek P, Andera L. (2013) The plant alkaloid and anti-leukemia drug homoharringtonine sensitizes resistant human colorectal carcinoma cells to TRAIL-induced apoptosis via multiple mechanisms. Apoptosis. 18:739-50. PubMed, DOI

2012

- Rárová L, Zahler S, Liebl J, Kryštof V, Sedlák D, Bartůněk P, Kohout L, Strnad M. (2012) Brassinosteroids inhibit in vitro angiogenesis in human endothelial cells. Steroids. 77:1502-9. PubMed, DOI

- Alquicer G, Sedlák D, Byun Y, Pavlíček J, Stathis M, Rojas C, Slusher B, Pomper MG, Bartůněk P, Bařinka C. (2012) Development of a high-throughput fluorescence polarization assay to identify novel ligands of glutamate carboxypeptidase II. J Biomol Screen. 17:1030-40. PubMed, DOI

- Hessler F, Císařová I, Sedlák D, Bartůněk P, Kotora M. (2012) Synthesis of ferrocenestrone: The first metallocene based steroid analogue. Chemistry. 27:5515-8. PubMed, DOI

2011

- Rejman D, Rabatinova A, Pombinho AR, Kovačková S, Pohl R, Zborníková E, Kolář M, Bogdanová K, Nyč O, Šanderová H, Látal T, Bartůněk P, Krásný L. (2011) Lipophosphonoxins: New modular molecular structures with significant antibacterial properties. J Med Chem. 54:7884-98. PubMed, DOI

- Sedlák D, Paguio A, Bartůněk P. (2011) Two panels of steroid receptor luciferase reporter cell lines for compound profiling. Comb Chem High Throughput Screen. 14:248-66. PubMed, DOI

 

ÚSTAV MOLEKULÁRNÍ A TRANSLAČNÍ MEDICÍNY, Olomouc

2016

- Agrawal K, Kaplánek V, Otmar M, Krečmerová M, Džubák P, Hajdúch M. (2016) Cell based DNA demethylation detection system for screening of epigenetic drugs in 2D, 3D, and xenograft models. Cytometry A. doi:10.1002/cyto.a.23004. PubMed, DOI

- Das V, Fürst T, Gurská S, Džubák P, Hajdúch M (2016) Reproducibility of Uniform Spheroid Formation in 384-Well Plates: The Effect of Medium Evaporation. Journal of Biomelecular Screening. 21(9): 923-30. PubMed, DOI

- Schadich E, Hlaváč J, Volná T, Varanasi L, Hajdúch M, Džubák P. (2016) Effects of Ginger Phenylpropanoids and Quercetin on Nrf2-ARE Pathway in Human BJ Fibroblasts and HaCaT Keratinocytes. BioMed Research International. 2016: 2173275. PubMed, DOI

2015

- Hezova R, Kovarikova A, Srovnal J, Zemanova M, Harustiak T, Ehrmann J, Hajdúch M, Sachlova M, Svoboda M, Slabý O. (2015) MiR-205 functions as a tumor suppressor in adenocarcinoma and an oncogene in squamous cell carcinoma of esophagus. Tumour Biol. 1-12. PubMed, DOI

- Sulovská L, Holub D, Židová Z, Divoka M, Hajdúch M, Mihál V, Vrbková J, Horváthová M, Pospíšilová D. (2015) Characterization of iron metabolism and erythropoiesis in erythrocyte membrane defects and thalassemia traits. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 160:231-7 PubMed, DOI

2014

- Nauš P, Caletková, O, Konečný P, Džubák P, Bogdanová K, Kolář M, Vrbková J, Slavětínská L, Tloušťová E, Perlíková P, Hajdúch M, Hocek M. (2014) Synthesis, cytostatic, antimicrobial, and anti-HCV activity of 6-substituted 7-(het)aryl-7-deazapurine ribonucleosides. J Med Chem. 57:1097-110. PubMed, DOI

- Snášel J, Nauš P, Dostál J, Hnízda A, Fanfrlík J, Brynda J, Bourderioux A, Dušek M, Dvořáková H, Stolaříková J, Zábranská H, Pohl R, Konečný P, Džubák P, Votruba I, Hajdúch M, Rezáčova P, Veverka V, Hocek M, Píchova I. (2014) Structural basis for inhibition of mycobacterial and human adenosine kinase by 7-substituted 7-(het)aryl-7-deazaadenine ribonucleosides. J Med Chem. 57:8268-79. PubMed, DOI

- Mattová J, Poučková P, Kučka J, Škodová M, Vetrík M, Štěpánek P, Urbánek P, Petrik M, Novy Z, Hrubý M. (2014) Chelating polymeric beads as potential therapeutics for Wilson's disease. Eur J Pharm Sci. 62:1-7. PubMed, DOI

- Das V, Sim DA, Miller JH. (2014) Effect of taxoid and nontaxoid site microtubule-stabilizing agents on axonal transport of mitochondria in untransfected and ECFP-htau40-transfected rat cortical neurons in culture. J Neurosci Res. 92:1155-66. PubMed, DOI

- Messina I, Popa I, Maier V, Soural M. (2014) Solid-phase synthesis of 5-noranagrelide derivatives. ACS Comb Sci. 16:33-8. PubMed, DOI

- McMaster C, Fülöpová V, Popa I, Grepl M, Soural M. (2014) Solid-phase synthesis of anagrelide sulfonyl analogues. ACS Comb Sci. 16:221-4. PubMed, DOI

- Cankařová N, Venia la A, Krchňák V. (2014) Polymer-supported stereoselective synthesis of tetrahydrobenzopyrazino-thiadiazinone dioxides via N-sulfonyl iminiums. ACS Comb Sci. 16:293-302. PubMed, DOI

- Motyka K, Stýskala J, Cankař P, Hlavac J. (2014) Fluorescence properties of selected benzo[c]phenanthridines. J Fluoresc. 24:1177-82. PubMed, DOI

- Kadric J, Motyka K, Dzubak P, Hajdúch M, Soural M. (2014) Synthesis, cytotoxic activity, and fluorescence properties of a set of novel 3-hydroxyquinolin-4(1H)-ones. Tetrahedron Lett. 55:3592-5. DOI

- Ventosa-Andrés P, Hradilová L, Krchňák V. (2014) Privileged structures as peptide backbone constraints: Polymer-supported stereoselective synthesis of benzimidazolinopiperazinone peptides. ACS Comb Sci. 16:359-66. PubMed, DOI

2013

- Jurášek M, Džubák P, Sedlák D, Dvořáková H, Hajdúch M, Bartůněk P, Drašar P. (2013) Preparation, preliminary screening of new types of steroid conjugates and their activities on steroid receptors. Steroids. 78:356-61. PubMed, DOI

2012

- Kollareddy M, Zheleva D, Dzubak P, Brahmkshatriya PS, Lepsik M, Hajduch M. (2012) Aurora kinase inhibitors: Progress towards the clinic. Invest New Drugs. 30:2411-32. PubMed, DOI

- Perlíková P, Konečný P, Nauš P, Snášel J, Votruba I, Džubák P, Pichová I, Hajdúch M, Hocek M. (2012) 6-Alkyl-, 6-aryl- or 6-hetaryl-7-deazapurine ribonucleosides as inhibitors of human or MTB adenosine kinase and potential antimycobacterial agents. MedChemComm. 4:1497-1500. DOI

- Hrabakova R, Kollareddy M, Tyleckova J, Halada P, Hajduch M, Gadher SJ, Kovarova H. (2012) Cancer cell resistance to aurora kinase inhibitors: Identification of novel targets for cancer therapy. J Proteome Res. 12:455-69. PubMed, DOI

- Tyleckova J, Hrabakova R, Mairychova K, Halada P, Radova L, Dzubak P, Hajduch M, Gadher SJ, Kovarova H. (2012) Cancer cell response to anthracyclines effects: Mysteries of the hidden proteins associated with these drugs. Int J Mol Sci. 13:15536-64. PubMed, DOI

- Caletková O, Lásiková A, Hajdúch M, Džubák P, Gracza T. (2012) Synthesis and antitumour activity of varitriol and its analogues. ARKIVOC. 2012:365-83. DOI

- Urban M, Vlk M, Džubák P, Hajdúch M, Šarek J. (2012) Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid. Bioorg Med Chem. 20:3666-74. PubMed, DOI

- Hradilová L, Poláková M, Dvořáková B, Hajdúch M, Petruš L. (2012) Synthesis and cytotoxicity of some D-mannose click conjugates with aminobenzoic acid derivatives. Carbohydr Res. 2012:1-6. PubMed, DOI

 

VYSOKÁ ŠKOLA CHEMICKO-TECHNOLOGICKÁ, Praha

2017

- Šícho M., de Bruyn Kops C., Stork C., Svozil D., Kirchmair J. (2017) FAME 2: Simple and Effective Machine Learning Model of Cytochrome P450 Regioselectivity. J Chem Inf Model. Aug 28;57(8):1832-1846. PubMed, DOI

2015

- Čech P, Hoksza D, Svozil D. (2015) MultiSETTER: Web server for multiple RNA structure comparison. BMC Bioinformatics. 16:253. PubMed, DOI

- Hoksza D., Svozil D. (2015) Multiple 3D RNA structure superposition using neighbor joining. IEEE/ACM Trans Comput Biol Bioinform. 12:520-530. PubMed, DOI

2014

- Schneider B, Černý J, Svozil D, Čech P, Gelly JP, de Brevern AG. (2014) Bioinformatic analysis of the protein/DNA interface. Nucleic Acids Res. 42:3381-94. PubMed, DOI

2013

- Čech P, Kukal J, Černý J, Schneider B, Svozil D. (2013) Automatic workflow for the classification of local DNA conformations. BMC Bioinformatics. 14:205. PubMed, DOI

2012

- Hoksza D, Svozil D. (2012) Efficient RNA pairwise structure comparison by SETTER method. Bioinformatics. 28:1858-64. PubMed, DOI

- Čech P, Svozil D, Hoksza D. (2012) SETTER: web server for RNA structure comparison. Nucleic Acids Res. 40:W42-8. PubMed, DOI

2011

- Čech P, Svozil D. (2011) mmView: A web-based viewer of the mmCIF format. BMC Res Notes. 4:121. PubMed, DOI

 

ÚSTAV CHEMIE PŘÍRODOVĚDECKÉ FAKULTY MASARYKOVY UNIVERZITY, Brno

- Kaushik S, Marques SM, Khirsariya P, Paruch K, Libichova L, Brezovsky J, Prokop Z, Chaloupkova R, Damborsky J. Impact of the access tunnel engineering on catalysis is strictly ligand-specific. FEBS J. 2018 Feb 25. [Epub ahead of print]. Pubmed, DOI

2017

- Hylsová M, Carbain B, Fanfrlík J, Musilová L, Haldar S, Köprülüoğlu C, Ajani H, Brahmkshatriya P S, Jorda R, Kryštof V, Hobza P, Echalier A, Paruch K, Lepšík M. (2017) Explicit Treatment of Active-site Waters Enhances Quantum Mechanical/Implicit Solvent Scoring: Inhibition of CDK2 by new Pyrazolo[1.5-a]Pyrimidines. Eur J Med Chem. 126:1118-1128.  DOI

- Nekardová M, Vymětalová L, Khirsariya P, Kováčová S,  Hylsová M, Jorda R, Kryštof V, Fanfrlík J, Hobza P, Paruch K. (2017) Structural Basis of Interaction of CDK2 with Roscovitine and its Analogues Having Bioisosteric Central Heterocycles. ChemPhysChem. In press, PubMed,

2016

- Zemanová J, Hylse O, Collaková J, Veselý P, Oltová A, Borský M, Zápražná K, Kašpárková M, Janovská P, Verner J, Kohoutek J, Dzimková M, Bryja V, Brychtová Y, Paruch K, Trbušek M. (2016) Chk1 Inhibition Significantly Potentiates Activity of Nucleoside Analogs in TP53-mutated B-Lymphoid Cells. Oncotarget.  7:62091-62106. PubMed, DOI

- Hill N, Paruch K, Švenda J. (2016) Late-stage Annulative Convergency in Natural Product Synthesis. Tetrahedron. 72:3345.  DOI

2015

- Amaro M, Brezovský J, Kováčová S, Sýkora J, Bednář D, Němec V, Lišková V, Kurumbang N, Beerens K, Chaloupková R, Paruch K, Hof M, Damborský J. (2015) Site-specific analysis of protein hydration based on unnatural amino acid fluorescence. J Am Chem Soc. 137:4988-92. PubMed, DOI

- Kováčová S, Adla SK, Maier L, Babiak M, Mizushina Y, Paruch K. (2015) Synthesis of carbocyclic analogs of dehydroaltenusin: Identification of a stable inhibitor of calf DNA polymerase α. Tetrahedron, 71:7575-82. DOI

2014

- Labroli MA, Dwyer MP, Popovici-Muller J, Pu Q, Richard J, Rosner K, Paruch K, Guzi TJ. (2014) Syntheses of 5´-amino-2´,5´-dideoxy-2´,2´-difluorocytidine derivatives as novel anticancer nucleoside analogs. Tetrahedron Lett. 55:598-602. DOI

- Maier L, Hylse O, Necas M, Trbusek M, Ytre-Arne M, Dalhus B, Bjoras M, Paruch K. (2014) New carbocyclic nucleosides: Synthesis of carbocyclic pseudoisocytidine and its analogs. Tetrahedron Lett. 55:3713-6. DOI

2013

- Amaro M, Brezovsky J, Kováčová S, Maier L, Chaloupková R, Sykora J, Paruch K, Damborský J, Hof M. (2013) Are time-dependent fluorescence shifts at the tunnel mouth of haloalkane dehalogenase enzymes dependent on the choice of the chromophore? J Phys Chem B. 117:7898-906. PubMed, DOI

- Brahmkshatriya PS, Dobeš P, Fanfrlik J, Rezáç J, Paruch K, Bronowska A, Lepšík M, Hobza P. (2013) Quantum mechanical scoring: Structural and energetic insights into cyclin-dependent kinase 2 inhibition by pyrazolo[1,5-a]pyrimidines. Curr Comput Aided Drug Des. 9:118-29. PubMed, DOI

- Dwyer MP, Keertikar K, Paruch K, Alvarez C, Labroli M, Poker C, Fischmann TO, Mayer-Ezell R, Bond R, Wang Y, Azevedo R, Guzi TJ. (2013) Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: A template-based approach. Bioorg Med Chem Lett. 23:6178-82. PubMed, DOI

2012

- Jorda R, Paruch K, Krystof V. (2012) Cyclin-dependent kinase inhibitors inspired by roscovitine: Purine bioisosteres. Curr Pharm Des. 18:2974-80. PubMed, DOI