The CZ-OPENSCREEN compound library was recently enhanced by including 9,944 of novel high-quality chemical compounds of the Advanced Diversity Set (selected from the Enamine's Advanced Diversity Library). The collection contains premium small molecules with lead-like properties (molecular ≤ 350, cLogP ≤ 3, and rotatable bonds ≤ 7 and/or valuable pharmacophores suc as carboxylic, primary amino and amide groups). The library is specific for representing synthetically new and unique chemotypes with sp3-rich molecular scaffolds, which are likely to interact with hardly druggable biological targets.